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BLUE REVIEWSM

for Providers

April 2024

Pharmacy Program Quarterly Update Changes Effective April 1, 2024 – Part 2


Contents
Drug List Changes
Drug List Additions – Effective April 1, 2024
Balanced Drug List Additions
Performance Drug List Additions
Performance Select Drug List Additions
Basic, Basic Multi-Tier, Enhanced, and Enhanced Multi-Tier Drug Lists Revisions
Other Drug List Additions
Balanced Drug List Additions
Performance Drug List Additions
Performance Select Drug List Additions
Basic, Basic Multi-Tier, Enhanced, and Enhanced Multi-Tier Drug Lists Revisions
Drug Tier Changes – As of April 1, 2024
Performance Drug List
Other Drug Tier Changes
Balanced Drug List Tier Changes
Performance Drug List Tier Changes
Performance Select Drug List Tier Changes
Utilization Management Program Changes
Dispensing Limit Changes
Basic, Enhanced, Balanced, Performance, Performance Select and Health Insurance Marketplace Drug Lists
Standard Utilization Management Program Updates
Change in Benefit Coverage for Select High-Cost Products

Reminder: The Quarterly Pharmacy Changes are published as articles in two parts. This part-2 article is a continuation of the April Quarterly Pharmacy Changes Part 1, which included changes that require member notification — drug list revisions/exclusions, dispensing limits, utilization management changes and general information on pharmacy benefit program updates. This article contains recent coverage additions, utilization management updates and any other pharmacy program updates.


Drug List Changes
Based on the availability of new prescription medications and Prime’s National Pharmacy and Therapeutics Committee’s review of changes in the pharmaceuticals market, some additions (new to coverage) and/or some coverage tier changes (drugs moved to a lower out-of-pocket payment level) will be made to the Blue Cross and Blue Shield of Oklahoma drug lists. Additions effective April 1, 2024, and prior updates are outlined below.
Drug List Additions – Effective April 1, 2024

Balanced Drug List Additions

Drug1

Condition

CIBINQO (abrocitinib tab 50 mg, 100 mg, 200 mg)

Atopic Dermatitis

KALYDECO (ivacaftor packet 5.8 mg)

Cystic fibrosis

LODOCO (colchicine (cardiovascular) tab 0.5 mg)

Cardiovascular Event Risk Reduction

LUMRYZ (sodium oxybate pack for oral er susp 4.5 gm, 6 gm, 7.5 gm, 9 gm)

Cataplexy

OPZELURA (ruxolitinib phosphate cream 1.5%)

Atopic Dermatitis, Vitiligo

ORLADEYO (berotralstat hcl cap 110 mg, 150 mg)

Hereditary Angioedema

ROZLYTREK (entrectinib pellet pack 50 mg)

Cancer

SOHONOS (palovarotene cap 1 mg, 1.5 mg, 2.5 mg, 5 mg, 10 mg)

Fibrodysplasia Ossificans Progressiva

TIBSOVO (ivosidenib tab 250 mg)

Cancer

XALKORI (crizotinib cap sprinkle 20 mg, 50 mg, 150 mg)

Cancer

XDEMVY (lotilaner ophth soln 0.25%)

Demodex Blepharitis

ZEPBOUND (tirzepatide) 2.5 mg/0.5 ml, 5 mg/0.5 ml, 7.5 mg/0.5 ml, 10 mg/0.5 ml, 12.5 mg/0.5 ml, 15 mg/0.5 ml

Weight Loss

Performance Drug List Additions

Drug1

Condition

CIBINQO (abrocitinib tab 50 mg, 100 mg, 200 mg)

Atopic Dermatitis

KALYDECO (ivacaftor packet 5.8 mg)

Cystic fibrosis

LUMRYZ (sodium oxybate pack for oral er susp 4.5 gm, 6 gm, 7.5 gm, 9 gm)

Cataplexy

ORLADEYO (berotralstat hcl cap 110 mg, 150 mg)

Hereditary Angioedema

ROZLYTREK (entrectinib pellet pack 50 mg)

Cancer

SOHONOS (palovarotene cap 1 mg, 1.5 mg, 2.5 mg, 5 mg, 10 mg)

Fibrodysplasia Ossificans Progressiva

vancomycin hcl for oral soln 50 mg/ml (base equivalent)

C. Difficile Infection, Staphylococcal Enterocolitis

XALKORI (crizotinib cap sprinkle 20 mg, 50 mg, 150 mg)

Cancer

ZEPBOUND (tirzepatide) 2.5 mg/0.5 ml, 5 mg/0.5 ml, 7.5 mg/0.5 ml, 10 mg/0.5 ml, 12.5 mg/0.5 ml, 15 mg/0.5 ml

Weight Loss

Performance Select Drug List Additions

Drug1

Condition

CIBINQO (abrocitinib tab 50 mg, 100 mg, 200 mg)

Atopic Dermatitis

KALYDECO (ivacaftor packet 5.8 mg)

Cystic fibrosis

LUMRYZ (sodium oxybate pack for oral er susp 4.5 gm, 6 gm, 7.5 gm, 9 gm)

Cataplexy

OPZELURA (ruxolitinib phosphate cream 1.5%)

Atopic Dermatitis, Vitiligo

ORLADEYO (berotralstat hcl cap 110 mg, 150 mg)

Hereditary Angioedema

ROZLYTREK (entrectinib pellet pack 50 mg)

Cancer

SOHONOS (palovarotene cap 1 mg, 1.5 mg, 2.5 mg, 5 mg, 10 mg)

Fibrodysplasia Ossificans Progressiva

TIBSOVO (ivosidenib tab 250 mg)

Cancer

vancomycin hcl for oral soln 50 mg/ml (base equivalent)

C. Difficile Infection, Staphylococcal Enterocolitis

XALKORI (crizotinib cap sprinkle 20 mg, 50 mg, 150 mg)

Cancer

XYOSTED (testosterone enanthate solution auto-injector 50 mg/0.5 ml, 75 mg/0.5 ml, 100 mg/0.5 ml)

Primary hypogonadism, hypogonadotrophic hypogonadism

ZEPBOUND (tirzepatide) 2.5 mg/0.5 ml, 5 mg/0.5 ml, 7.5 mg/0.5 ml, 10 mg/0.5 ml, 12.5 mg/0.5 ml, 15 mg/0.5 ml

Weight Loss

Basic, Basic Multi-Tier, Enhanced, and Enhanced Multi-Tier Drug Lists Revisions

Drug1

Drug Class/Condition

BREO ELLIPTA (fluticasone furoate-vilanterol aero powd ba 50-25 mcg/act)

Asthma

CIBINQO (abrocitinib tab 50 mg, 100 mg, 200 mg)

Atopic Dermatitis

INSULIN GLARGINE-YFGN (insulin glargine-yfgn inj 100 unit/ml)

Diabetes

KALYDECO (ivacaftor packet 5.8 mg)

Cystic fibrosis

ROZLYTREK (entrectinib pellet pack 50 mg)

Cancer

TIBSOVO (ivosidenib tab 250 mg)

Cancer

XALKORI (crizotinib cap sprinkle 20 mg, 50 mg, 150 mg)

Cancer


Other Drug List Additions
Most additions to the drug list become effective quarterly, however, some drugs are added as part of formulary maintenance (e.g., new strength of covered drug) or re-evaluated during the quarter then added to the list. Those drugs are listed below.

Balanced Drug List Additions

Drug1

Condition

Effective Date

ADTHYZA (thyroid tab 15 mg (1/4 grain), 30 mg (1/2 grain), 60 mg (1 grain), 90 mg (1 1/2 grain), 120 mg (2 grain))

Hypothyroidism

1/7/2024

ANALPRAM-HC (hydrocortisone acetate w/ pramoxine perianal cream 1-1%)

Pruritus, Dermatoses

1/21/2024

bromfenac sodium ophth soln 0.075% (base equivalent)

Inflammation-Ophthalmic

2/11/2024

CLONIDINE HYDROCHLORIDE ER (clonidine hcl tab er 24 hr 0.17 mg (base equivalent))

Hypertension

1/14/2024

dabigatran etexilate mesylate cap 110 mg (etexilate base eq)

Thromboembolism/Stroke Prevention, DVT/PE Prevention and Treatment

2/11/2024

deflazacort tab 6 mg, 18 mg, 30 mg, 36 mg

Duchenne Muscular Dystrophy

2/11/2024

gabapentin (once-daily) tab 300 mg, 600 mg

Post-herpetic Neuralgia

1/28/2024

GLOPERBA (colchicine oral soln 0.6 mg/5 ml)

Gout prevention

1/22/2024

HEMLIBRA (emicizumab-kxwh subcutaneous soln 300 mg/2 ml (150 mg/ml))

Hemophilia A

1/14/2024

indomethacin susp 25 mg/5 ml

Inflammatory Conditions

1/21/2024

JYNNEOS (smallpox & monkeypox vac, live, non-replicating inj 0.5 ml)

Smallpox and Monkeypox Vaccine

2/1/2024

LOCOID LIPOCREAM (hydrocortisone butyrate hydrophilic lipo base cream 0.1%)

Dermatitis, Dermatoses

1/21/2024

loteprednol etabonate ophth susp 0.2%

Ocular Inflammation/Pain

2/11/2024

METHYLPHENIDATE ER TABLETS 24 HR 18 mg

attention deficit-hyperactivity disorder (ADHD)

3/1/2024

methylphenidate er tablets 27 mg, 36 mg and 54 mg

attention deficit-hyperactivity disorder (ADHD)

3/1/2024

mifepristone tab 300 mg

Cushing’s Syndrome

1/28/2024

OMNIPOD 5 G7 INTRO KIT (G EN 5) (insulin infusion disposable pump kit)

Diabetes

2/4/2024

OMNIPOD 5 G7 PODS (GEN 5) (insulin infusion disposable pump reservoir)

Diabetes

2/4/2024

teriparatide (recombinant) soln pen-inj 600 mcg/2.4 ml

Osteoporosis

1/7/2024

TRAMADOL HYDROCHLORIDE (tramadol hcl tab 25 mg)

Pain

1/7/2024

VANFLYTA (quizartinib dihydrochloride tab 17.7 mg, 26.5 mg)

Cancer

3/1/2024

Performance Drug List Additions

Drug1

Condition

Date Added

ADTHYZA (thyroid tab 15 mg (1/4 grain), 30 mg (1/2 grain), 60 mg (1 grain), 90 mg (1 1/2 grain), 120 mg (2 grain))

Hypothyroidism

1/7/2024

ANALPRAM-HC (hydrocortisone acetate w/ pramoxine perianal cream 1-1%)

Pruritus, Dermatoses

1/21/2024

dabigatran etexilate mesylate cap 110 mg (etexilate base eq)

Thromboembolism/Stroke Prevention, DVT/PE Prevention and Treatment

2/11/2024

HEMLIBRA (emicizumab-kxwh subcutaneous soln 300 mg/2 ml (150 mg/ml))

Hemophilia A

1/14/2024

JYNNEOS (smallpox & monkeypox vac, live, non-replicating inj 0.5 ml)

Smallpox and Monkeypox Vaccine

2/1/2024

loteprednol etabonate ophth susp 0.2%

Ocular Inflammation/Pain

2/11/2024

METHYLPHENIDATE ER TABLETS 24 HR 18 mg

attention deficit-hyperactivity disorder (ADHD)

3/1/2024

methylphenidate er tablets 27 mg, 36 mg and 54 mg

attention deficit-hyperactivity disorder (ADHD)

3/1/2024

mifepristone tab 300 mg

Cushing’s Syndrome

1/28/2024

OMNIPOD 5 G7 INTRO KIT (G EN 5) (insulin infusion disposable pump kit)

Diabetes

2/4/2024

OMNIPOD 5 G7 PODS (GEN 5) (insulin infusion disposable pump reservoir)

Diabetes

2/4/2024

teriparatide (recombinant) soln pen-inj 600 mcg/2.4 ml

Osteoporosis

1/7/2024

VANFLYTA (quizartinib dihydrochloride tab 17.7 mg, 26.5 mg)

Cancer

3/1/2024

Performance Select Drug List Additions

Drug1

Condition

Date Added

ADTHYZA (thyroid tab 15 mg (1/4 grain), 30 mg (1/2 grain), 60 mg (1 grain), 90 mg (1 1/2 grain), 120 mg (2 grain))

Hypothyroidism

1/7/2024

ANALPRAM-HC (hydrocortisone acetate with pramoxine perianal cream 1-1%)

Pruritus, Dermatoses

1/21/2024

bromfenac sodium ophth soln 0.075% (base equivalent)

Inflammation-Ophthalmic

2/11/2024

dabigatran etexilate mesylate cap 110 mg (etexilate base eq)

Thromboembolism/ Stroke Prevention, DVT/PE Prevention and Treatment

2/11/2024

gabapentin (once-daily) tab 300 mg, 600 mg

Post-herpetic Neuralgia

1/28/2024

HEMLIBRA (emicizumab-kxwh subcutaneous soln 300 mg/2 ml (150 mg/ml))

Hemophilia A

1/14/2024

JYNNEOS (smallpox & monkeypox vac, live, non-replicating inj 0.5 ml)

Smallpox and Monkeypox Vaccine

2/1/2024

loteprednol etabonate ophth susp 0.2%

Ocular Inflammation/Pain

2/11/2024

METHYLPHENIDATE ER TABLETS 24 HR 18 mg

attention deficit-hyperactivity disorder (ADHD)

3/1/2024

methylphenidate er tablets 27 mg, 36 mg and 54 mg

attention deficit-hyperactivity disorder (ADHD)

3/1/2024

mifepristone tab 300 mg

Cushing’s Syndrome

1/28/2024

OMNIPOD 5 G7 INTRO KIT (GEN 5) (insulin infusion disposable pump kit)

Diabetes

2/4/2024

OMNIPOD 5 G7 PODS (GEN 5) (insulin infusion disposable pump reservoir)

Diabetes

2/4/2024

teriparatide (recombinant) soln pen-inj 600 mcg/2.4 ml

Osteoporosis

1/7/2024

VANFLYTA (quizartinib dihydrochloride tab 17.7 mg, 26.5 mg)

Cancer

3/1/2024

Basic, Basic Multi-Tier, Enhanced, and Enhanced Multi-Tier Drug Lists Revisions

Drug1

Condition

Date Added

HEMLIBRA (emicizumab-kxwh subcutaneous soln 300 mg/2 ml (150 mg/ml))

Hemophilia A

1/14/2024

XOLAIR (omalizumab subcutaneous soln auto-injector 75 mg/0.5 ml, 300 mg/2 ml, 150 mg/ml)

Moderate to severe asthma, Chronic rhinosinusitis with nasal polyps, Chronic spontaneous urticaria

2/18/2024

XOLAIR (omalizumab subcutaneous soln prefilled syringe
300 mg/2 ml)

Moderate to severe asthma,
Chronic rhinosinusitis with nasal polyps, Chronic spontaneous urticaria

2/18/2024


Drug Tier Changes – As of April 1, 2024
The tier changes listed below apply to members on a managed drug list. Tier changes effective April 1, 2024 are listed below.

Performance Drug List

Drug1

Condition

New Lower Tier

TIBSOVO (ivosidenib tab 250 mg)

Cancer

Preferred Brand


Other Drug Tier Changes
Most tier changes become effective quarterly, however, some drugs are moved to a new tier as part of formulary maintenance or re-evaluated during the quarter. Those drugs are listed below with their addition date.

Balanced Drug List Tier Changes
Drug1 Condition New Lower Tier Effective Date
albuterol sulfate soln nebu 0.5% (5 mg/ml) Asthma Non-Preferred Generic 2/11/2024
VALSARTAN (valsartan oral soln 4 mg/ml) Heart failure, Hypertension,
Cardiovascular risk reduction
post-myocardial infarction

Non-Preferred Generic

1/7/2024

Performance Drug List Tier Changes

Drug1

Condition

New Lower Tier

Effective Date

albuterol sulfate soln nebu 0.5% (5 mg/ml)

Asthma

Non-Preferred Generic

2/11/2024

Performance Select Drug List Tier Changes

Drug1

Condition

New Lower Tier

Effective Date

albuterol sulfate soln nebu 0.5% (5 mg/ml)

Asthma

Non-Preferred Generic

2/11/2024


Utilization Management Program Changes
Utilization Management programs are implemented to regularly review the appropriateness of medications within drug-therapy programs, and as a result, may adjust dispensing limits, prior authorization or step-therapy requirements. The following drug programs reflect those changes.

Dispensing Limit Changes
BCBSOK’s prescription drug benefit program includes coverage limits on certain medications and drug categories. Dispensing limits, or quantity limits, are based on U.S. Food and Drug Administration approved dosage regimens and product labeling. New dispensing limits and effective dates are listed on the chart below.

Basic, Enhanced, Balanced, Performance, Performance Select and Health Insurance Marketplace Drug Lists

Clinical Program

Medication(s)1

New Dispensing Limit

Effective Date

Keveyis PAQL

Keveyis (dichlorphenamide) 50 mg tab

Program retired

3/15/2024

Therapeutic Alternatives PAQL

Metaxalone 400 mg tab

Target retired

4/15/2024


Standard Utilization Management Program Updates
Prior authorization and Step Therapy programs for standard-pharmacy benefit plans correlate to a member's drug list. Not all standard programs apply since updates are based on the member's current drug list. The prescription drugs tab on bcbsok.com lists the pharmacy programs per drug list, current drug lists and dispensing limits.

If your patients have any questions about their pharmacy benefits, please advise them to contact the number on their member ID card. Members may also log in to Blue Access for MembersSM or MyPrime.com for a variety of online resources.

Program Changes
The following standard utilization management programs were updated on the dates indicated below.

Program Retirements
The following standard utilization management programs have been retired on the dates indicated below.


Please Note: The prior authorization programs for standard pharmacy benefit plans correlate to a member's drug list. Not all standard PA programs may apply, based on the member's current drug list. A list of PA programs per drug list is posted on the member pharmacy programs section of bcbsok.com.

If your patients have any questions about their pharmacy benefits, please advise them to contact the number on their member ID card. Members may also log in to Blue Access for MembersSM or MyPrime.com for a variety of online resources.

Change in Benefit Coverage for Select High-Cost Products
Several high-cost products with available lower cost alternatives will be excluded on the pharmacy benefit for select drug lists. This change impacts BCBSOK members who have prescription-drug benefits administered by Prime Therapeutics†. This change is part of an ongoing effort to ensure our members and employer groups have access to safe, cost-effective medications.
Please note: Members were not notified of this change because either there is no utilization, or the pharmacist can easily fill a member's prescription with the equivalent without needing a new prescription from the doctor. The following drugs are excluded on select drug lists.

Product(s) No Longer Covered1

Condition

Covered Alternative(s)1,2

KETOPROFEN 25 mg capsules

Pain

meloxicam, ibuprofen, naproxen


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1Third-party brand names are the property of their respective owner. 

2This list is not all inclusive. Other medicines may be available in this drug class. 

3Coverage of medications is still subject to the limits, exclusions and out-of-pocket requirements based on the member’s plan. 

Please note: If coverage of the member’s medication is changed on their prescription drug list, the amount the member will pay for the same medication under this preventive drug benefit may also change. 

†Prime Therapeutics LLC is a pharmacy benefit management company. BCBSOK contracts with Prime to provide pharmacy benefit management and related other services. BCBSOK, as well as several independent Blue Cross and Blue Shield Plans, has an ownership interest in Prime. MyPrime.com is an online resource offered by Prime Therapeutics. 

The information mentioned here is for informational purposes only and is not a substitute for the independent medical judgment of a physician. Physicians are to exercise their own medical judgment. Pharmacy benefits and limits are subject to the terms set forth in the member’s certificate of coverage which may vary from the limits set forth above. The listing of any drug or classification of drugs is not a guarantee of benefits. Members should refer to their certificate of coverage for more details, including benefits, limitations and exclusions. Regardless of benefits, the final decision about any medication is between the member and their health care provider.